双联抗血小板聚集治疗(DAPT)对于老年患者缺血性卒中(IS)或短暂性脑缺血发作(TIA)后的二级预防的疗效和安全性尚不清楚。来自北京协和医院神经科的彭斌教授团队,对老年IS或TIA患者中采用双联和单一抗血小板聚集治疗进行系统评价和荟萃分析。文章近日发表在European Journal of Neurology上。
OTT:发病至治疗时间;ESPS2:Second European Stroke Prevention Study;MATCH:Management of Atherothrombosis with Clopidogrel in High-Risk Patients with Recent Transient Ischaemic Attack or Ischaemic Stroke;ESPRIT:European/Australasian Stroke Prevention in Reversible Ischaemia Trial;PRoFESS:Prevention Regimen for Effectively Avoiding Second Strokes;SPS3:皮质下小卒中的二级预防;CHANCE:Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events;COMPRESS, Combination of Clopidogrel and Aspirin for Prevention of Recurrence in Acute Atherothrombotic Stroke Study;OXVASC:Oxford Vascular Study;TIA:短暂性脑缺血发作;IS:缺血性中风;DP:双嘧达莫;ASA:阿司匹林;LAA:大动脉粥样硬化;NA:无数据/不可用
[参考文献]
Ding L, Peng B.Efficacy and Safety of Dual Antiplatelet Therapy in the Elderly for Stroke Prevention: A SystematicReviewand Meta-Analysis.Eur J Neurol. 2018 Jun 1. [Epub ahead of print]